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KMID : 0861020020170010029
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Korea Journal of Herbology
2002 Volume.17 No. 1 p.29 ~ p.38
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Effect of Ephedrae Herba on Release of MCP - 1 , MCP - 2 , and MCP - 3 of Monocyte Chemotactic Proteins in Human Nasal Mucosal Fibroblasts
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Abstract
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Recent reports have proposed that Ephedrae Herba may modulate the immune response on allergy or asthma. Human nasal mucosal fibroblasts are a rich source cytokines, inflammatory mediators, and chemokines. Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense.
Objectives : The objective of this study was to investigate the effect of Ephedrae Herba on the release of the chemokines such as monocyte chemotactic protein(MCP)-1, MCP-2, and MCP-3 in human nasal mucosal fibroblasts after stimulation with cytokines like tumor necrosis factor -α(TNF-α), interferon-γ(IFN-γ), and interleukin -1β(IL-1β).
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